Dose‐dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor - Jin, Yan; Regev, Arie; Kam, Jeanelle; Phipps, Krista; Smith, Claire; Henck, Judith; Campanale, Kristina; Hu, Leijun; Hall, D. Greg; Yang, Xiao Yan; Nakano, Masako; McNearney, Terry Ann; et al. (British journal of clinical pharmacology, 2018)
Keywords: Administration, Oral; Adult; Area Under Curve; Celecoxib - adverse effects; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - pathology; Cyclooxygenase 2 Inhibitors - adverse effects; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Hypersensitivity - etiology; Drug Hypersensitivity - pathology; Drug Safety; drug‐induced liver injury; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - pharmacokinetics; Enzyme Inhibitors - pharmacology; eosinophilia; Female; Half-Life; Healthy Volunteers; hepatocellular injury; Humans; Imidazoles - administration & dosage; Imidazoles - adverse effects; Imidazoles - pharmacokinetics; Imidazoles - pharmacology; Liver - drug effects; Liver - immunology; Liver - pathology; Male; Middle Aged; nonsteroidal anti‐inflammatory drugs; Pain - drug therapy; Prostaglandin-E Synthases - antagonists & inhibitors; rashes; Withholding Treatment; drug-induced liver injury; nonsteroidal anti-inflammatory drugs; eosinophilia; hepatocellular injury; rashes