Current insights into the role of human β‐defensins in atopic dermatitis

• Published in: Clinical and experimental immunology Vol. 190; no. 2; pp. 155 - 166
• Main Authors: Chieosilapatham, P., Ogawa, H., Niyonsaba, F.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.11.2017
• Subjects: Animals; anti‐microbial peptide; atopic dermatitis; beta-Defensins - biosynthesis; beta-Defensins - genetics; beta-Defensins - immunology; beta-Defensins - metabolism; Dermatitis, Atopic - immunology; Dermatitis, Atopic - physiopathology; Dermatitis, Atopic - therapy; host defence peptide; human β‐defensins; Humans; inflammation; Mice; Review; atopic dermatitis; host defence peptide; inflammation; anti-microbial peptide; human β-defensins

Summary Anti‐microbial peptides or host defence peptides are small molecules that display both anti‐microbial activities and complex immunomodulatory functions to protect against various diseases. Among these peptides, the human β‐defensins (hBDs) are localized primarily in epithelial surfaces, incl...