A phase 1 study of prasugrel in patients with sickle cell disease: pharmacokinetics and effects on ex vivo platelet reactivity - Jakubowski, Joseph A.; Zhou, Chunmei; Small, David S.; Winters, Kenneth J.; Lachno, D. Richard; Frelinger, Andrew L.; Howard, Jo; Mant, Timothy G.; Jurcevic, Stipo; Payne, Christopher D. (British journal of clinical pharmacology, 2013)
Keywords: adenosine diphosphate; Adult; Anemia, Sickle Cell - drug therapy; Anemia, Sickle Cell - metabolism; Blood Platelets - drug effects; Clinical Trials; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Male; P2Y12 receptor antagonist; Piperazines - adverse effects; Piperazines - pharmacokinetics; Piperazines - pharmacology; platelet; Platelet Function Tests; prasugrel; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists - adverse effects; Purinergic P2 Receptor Antagonists - pharmacokinetics; Purinergic P2 Receptor Antagonists - pharmacology; sickle cell; Thiophenes - adverse effects; Thiophenes - pharmacokinetics; Thiophenes - pharmacology; Young Adult