Down‐regulation of aquaporin 5‐mediated epithelial‐mesenchymal transition and anti‐metastatic effect by natural product Cairicoside E in colorectal cancer

• Published in: Molecular carcinogenesis Vol. 56; no. 12; pp. 2692 - 2705
• Main Authors: Chen, Chen, Ma, Ting, Zhang, Chao, Zhang, Hao, Bai, Lijuan, Kong, Lingyi, Luo, Jianguang
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2017
• Subjects: Animals; Aquaporin 5; Aquaporin 5 - genetics; Aquaporin 5 - metabolism; Aquaporins; Biological Products - chemistry; Biological Products - pharmacology; Blotting, Western; Cairicoside E; Cell Line, Tumor; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Cytotoxicity; Down-Regulation - drug effects; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - genetics; epithelial‐mesenchymal transition; Gene Expression Regulation, Neoplastic - drug effects; Glycolipids - chemistry; Glycolipids - pharmacology; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Ipomoea cairica; Lung nodules; Mesenchyme; Metastases; Metastasis; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasm Metastasis; RNA Interference; Smad2 protein; Transforming growth factor-b1; tumor metastasis; Xenograft Model Antitumor Assays; epithelial-mesenchymal transition; Cairicoside E; colorectal cancer; tumor metastasis; aquaporin 5

Epithelial‐mesenchymal transition (EMT) has emerged as an important determinant role in colorectal cancer (CRC) metastasis. It has been reported that aquaporin 5 (AQP5) is closely linked to CRC metastasis. However, the effect of AQP5 on the EMT process of CRC remains unknown. The current study showe...