Rapid quantitative detection system for measles virus-neutralizing antibodies using HiBiT-tagged virus-like particles

• Published in: Microbiology and immunology Vol. 68; no. 4; p. 160
• Main Authors: Okura, Takashi, Miyakawa, Kei, Tahara, Maino, Someya, Kenji, Seki, Fumio, Nishi, Mayuko, Otsuki, Noriyuki, Ryo, Akihide
• Format: Journal Article
• Language: English
• Published: Australia 01.04.2024
• Subjects: fusion; virus‐like particles; hemagglutinin; HiBiT; LgBiT; virus neutralization test; measles virus

Immunological testing to detect neutralizing antibodies (NAbs) is important in measles (MV) infection control. Currently, the plaque reduction neutralization test is the only credible method for measuring actual virus NAbs; however, its feasibility is hampered by drawbacks, such as long turnaround t...