Intracerebral hemorrhage‐induced brain injury in mice: The role of peroxiredoxin 2‐Toll‐like receptor 4 inflammatory axis

• Published in: CNS neuroscience & therapeutics Vol. 30; no. 3; pp. e14681 - n/a
• Main Authors: Du, Yang, Wang, Jinjin, Zhang, Jia, Li, Ning, Li, Guangshuo, Liu, Xinmin, Lin, Yijun, Wang, Dandan, Kang, Kaijiang, Bian, Liheng, Zhao, Xingquan
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2024
• Subjects: Antibodies; Blood; Brain injury; Brain research; Cell activation; Erythrocytes; Hemorrhage; Histology; Immunofluorescence; Immunohistochemistry; Inflammation; Injection; intracerebral hemorrhage; Leukocytes (neutrophilic); Macrophages; Magnetic resonance imaging; mice; Microglia; Neuroimaging; Neurological diseases; Pathogens; Peroxiredoxin; peroxiredoxin 2; Proteins; Redox reactions; Stroke; Therapeutic targets; TLR4; TLR4 protein; Toll-like receptors; Beijing China; United Kingdom > UK; United States > US; Colorado; Massachusetts; China; California; intracerebral hemorrhage; peroxiredoxin 2; brain injury; inflammation; TLR4; mice

Background Peroxiredoxin 2 (Prx2), an intracellular protein that regulates redox reactions, released from red blood cells is involved in inflammatory brain injury after intracerebral hemorrhage (ICH). Toll‐like receptor 4 (TLR4) may be crucial in this process. This study investigated the role of the...