Role of IL‐6 in dendritic cell functions

Dendritic cells (DCs) are efficient antigen‐presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly involved in cellular and humoral immune responses by presenting antigens to initiate T cell reactions, cytokine and chemokine secretion, T cell di...

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Published inJournal of leukocyte biology Vol. 111; no. 3; pp. 695 - 709
Main Authors Xu, Yu‐Dong, Cheng, Mi, Shang, Pan‐Pan, Yang, Yong‐Qing
Format Journal Article
LanguageEnglish
Published United States 01.03.2022
Subjects
dendritic cells (DCs)
IL‐6
immune response
immune response
dendritic cells (DCs)
IL-6
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Abstract Dendritic cells (DCs) are efficient antigen‐presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly involved in cellular and humoral immune responses by presenting antigens to initiate T cell reactions, cytokine and chemokine secretion, T cell differentiation and expansion, B cell activation and regulation, and the mediation of immune tolerance. The functions of DCs depend on their activation status, which is defined by the stages of maturation, phenotype differentiation, and migration ability, among other factors. IL‐6 is a soluble mediator mainly produced by a variety of immune cells, including DCs, that exerts pleiotropic effects on immune and inflammatory responses through interaction with specific receptors expressed on the surface of target cells. Here, we review the role of IL‐6, when generated in an inflammatory context or as derived from DCs, in modulating the biologic function and activation status of DCs and emphasize the importance of searching for novel strategies to target the IL‐6/IL‐6 signaling pathway as a means to diminish the inflammatory activity of DCs in immune response or to prime the immunogenic activity of DCs in immunosuppressive conditions. Graphical Reviews the role of IL‐6, when generated in an inflammatory context or as derived from dendritic cells (DCs), in modulating the biological function and activation status of DCs.
AbstractList Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly involved in cellular and humoral immune responses by presenting antigens to initiate T cell reactions, cytokine and chemokine secretion, T cell differentiation and expansion, B cell activation and regulation, and the mediation of immune tolerance. The functions of DCs depend on their activation status, which is defined by the stages of maturation, phenotype differentiation, and migration ability, among other factors. IL-6 is a soluble mediator mainly produced by a variety of immune cells, including DCs, that exerts pleiotropic effects on immune and inflammatory responses through interaction with specific receptors expressed on the surface of target cells. Here, we review the role of IL-6, when generated in an inflammatory context or as derived from DCs, in modulating the biologic function and activation status of DCs and emphasize the importance of searching for novel strategies to target the IL-6/IL-6 signaling pathway as a means to diminish the inflammatory activity of DCs in immune response or to prime the immunogenic activity of DCs in immunosuppressive conditions.
Dendritic cells (DCs) are efficient antigen‐presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly involved in cellular and humoral immune responses by presenting antigens to initiate T cell reactions, cytokine and chemokine secretion, T cell differentiation and expansion, B cell activation and regulation, and the mediation of immune tolerance. The functions of DCs depend on their activation status, which is defined by the stages of maturation, phenotype differentiation, and migration ability, among other factors. IL‐6 is a soluble mediator mainly produced by a variety of immune cells, including DCs, that exerts pleiotropic effects on immune and inflammatory responses through interaction with specific receptors expressed on the surface of target cells. Here, we review the role of IL‐6, when generated in an inflammatory context or as derived from DCs, in modulating the biologic function and activation status of DCs and emphasize the importance of searching for novel strategies to target the IL‐6/IL‐6 signaling pathway as a means to diminish the inflammatory activity of DCs in immune response or to prime the immunogenic activity of DCs in immunosuppressive conditions. Graphical Reviews the role of IL‐6, when generated in an inflammatory context or as derived from dendritic cells (DCs), in modulating the biological function and activation status of DCs.
Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly involved in cellular and humoral immune responses by presenting antigens to initiate T cell reactions, cytokine and chemokine secretion, T cell differentiation and expansion, B cell activation and regulation, and the mediation of immune tolerance. The functions of DCs depend on their activation status, which is defined by the stages of maturation, phenotype differentiation, and migration ability, among other factors. IL-6 is a soluble mediator mainly produced by a variety of immune cells, including DCs, that exerts pleiotropic effects on immune and inflammatory responses through interaction with specific receptors expressed on the surface of target cells. Here, we review the role of IL-6, when generated in an inflammatory context or as derived from DCs, in modulating the biologic function and activation status of DCs and emphasize the importance of searching for novel strategies to target the IL-6/IL-6 signaling pathway as a means to diminish the inflammatory activity of DCs in immune response or to prime the immunogenic activity of DCs in immunosuppressive conditions.Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly involved in cellular and humoral immune responses by presenting antigens to initiate T cell reactions, cytokine and chemokine secretion, T cell differentiation and expansion, B cell activation and regulation, and the mediation of immune tolerance. The functions of DCs depend on their activation status, which is defined by the stages of maturation, phenotype differentiation, and migration ability, among other factors. IL-6 is a soluble mediator mainly produced by a variety of immune cells, including DCs, that exerts pleiotropic effects on immune and inflammatory responses through interaction with specific receptors expressed on the surface of target cells. Here, we review the role of IL-6, when generated in an inflammatory context or as derived from DCs, in modulating the biologic function and activation status of DCs and emphasize the importance of searching for novel strategies to target the IL-6/IL-6 signaling pathway as a means to diminish the inflammatory activity of DCs in immune response or to prime the immunogenic activity of DCs in immunosuppressive conditions.
Author Cheng, Mi
Xu, Yu‐Dong
Shang, Pan‐Pan
Yang, Yong‐Qing
Author_xml – sequence: 1
  givenname: Yu‐Dong
  surname: Xu
  fullname: Xu, Yu‐Dong
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  organization: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
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  givenname: Mi
  surname: Cheng
  fullname: Cheng, Mi
  organization: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
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  givenname: Pan‐Pan
  surname: Shang
  fullname: Shang, Pan‐Pan
  organization: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
– sequence: 4
  givenname: Yong‐Qing
  surname: Yang
  fullname: Yang, Yong‐Qing
  email: yyq@shutcm.edu.cn
  organization: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
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  article-title: Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
  publication-title: Immunity
  doi: 10.1016/S1074-7613(03)00208-5
– volume: 58
  start-page: 1741
  year: 2008
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  article-title: Direct B cell stimulation by dendritic cells in a mouse model of lupus
  publication-title: Arthritis Rheum
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Snippet Dendritic cells (DCs) are efficient antigen‐presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly...
Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link between the innate and adaptive immune systems. These cells are broadly...
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SubjectTerms dendritic cells (DCs)
IL‐6
immune response
Title Role of IL‐6 in dendritic cell functions
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2FJLB.3MR0621-616RR
https://www.ncbi.nlm.nih.gov/pubmed/34405445
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