Characterizing the molecular and immune landscape of canine bladder cancer

• Published in: Veterinary & comparative oncology Vol. 20; no. 1; pp. 69 - 81
• Main Authors: Cronise, Kathryn E., Das, Sunetra, Hernandez, Belen G., Regan, Daniel P., Dailey, Deanna D., McGeachan, Robert I., Lana, Susan E., Page, Rodney L., Gustafson, Daniel L., Duval, Dawn L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2022
• Subjects: Animals; bladder cancer; BRAF; canine; Carcinoma, Transitional Cell - genetics; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - veterinary; Dog Diseases - genetics; Dog Diseases - pathology; Dogs; immunotherapy; PD‐L1; Proto-Oncogene Proteins B-raf - genetics; Transcriptome; transitional cell carcinoma; Tumor Microenvironment; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - veterinary; urothelial carcinoma; urothelial carcinoma; bladder cancer; immunotherapy; PD-L1; BRAF; canine; transitional cell carcinoma

Transitional cell carcinoma (TCC), also known as urothelial carcinoma, is the most common bladder cancer in humans and dogs. Approximately one‐quarter of human TCCs are muscle‐invasive and associated with a high risk of death from metastasis. Canine TCC (cTCC) tumours are typically high‐grade and mu...