An integrated PK‐PD model for cortisol and the 17‐hydroxyprogesterone and androstenedione biomarkers in children with congenital adrenal hyperplasia

• Published in: British journal of clinical pharmacology Vol. 87; no. 3; pp. 1098 - 1110
• Main Authors: Al‐Kofahi, Mahmoud, Ahmed, Mariam A., Jaber, Mutaz M., Tran, Thang N., Willis, Brian A., Zimmerman, Cheryl L., Gonzalez‐Bolanos, Maria T., Brundage, Richard C., Sarafoglou, Kyriakie
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.03.2021
• Subjects: compartmental analysis; endocrinology; mathematical modelling; Original; paediatric; population pharmacokinetics‐pharmacodynamics; steroids; steroids; mathematical modelling; compartmental analysis; endocrinology; paediatric; population pharmacokinetics-pharmacodynamics

Aims The aim of this study was to characterize the pharmacokinetic/pharmacodynamic relationships of cortisol and the adrenal biomarkers 17‐hydroxyprogesterone and androstenedione in children with congenital adrenal hyperplasia (CAH). Methods A nonlinear mixed‐effect modelling approach was used to an...