Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review

• Published in: Journal of neuro-oncology Vol. 167; no. 1; pp. 201 - 210
• Main Authors: Kegoya, Yasuhito, Otani, Yoshihiro, Inoue, Yohei, Mizuta, Ryo, Higaki, Fumiyo, Washio, Kana, Koizumi, Shinichiro, Kurozumi, Kazuhiko, Ishida, Joji, Fujii, Kentaro, Yamamoto, Norio, Tanaka, Yoshihiro, Date, Isao
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2024; Springer Nature B.V
• Subjects: Adult; Basal ganglia; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Brain stem; Case Study; Cerebrum; Child; Corpus callosum; Frontal lobe; Glioma; Glioma - diagnostic imaging; Glioma - genetics; Histones - genetics; Humans; Magnetic resonance imaging; Male; Medical prognosis; Medicine; Medicine & Public Health; Mutants; Mutation; Neurology; Oncology; Patients; Pediatrics; Prognosis; Regression analysis; Survival; Young Adult; Diffuse hemispheric gliomas, H3 G34-mutation; Frontal lobe; Midline invasion; Gross total resection

Introduction Diffuse hemispheric glioma, H3 G34-mutant (DHGs), is a newly categorized tumor in pediatric-type diffuse high-grade gliomas, World Health Organization grade 4, with a poor prognosis. Although prognostic factors associated with genetic abnormalities have been reported, few reports have e...