IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects

• Published in: Immunology letters Vol. 152; no. 2; pp. 104 - 108
• Main Authors: Inanir, Ahmet, Yigit, Serbulent, Tekcan, Akın, Tural, Sengul, Kismali, Gorkem
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2013
• Subjects: Adult; Allergy and Immunology; Arthritis, Rheumatoid - genetics; Female; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-4 - genetics; Interleukin-4 gene (IL-4); Male; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Methylenetetrahydrofolate reductase gene (MTHFR); Middle Aged; Minisatellite Repeats - genetics; Polymorphism; Polymorphism, Single Nucleotide; Rheumatiod arthritis; Risk Factors; Turkey; Turkey; Methylenetetrahydrofolate reductase gene (MTHFR); Rheumatiod arthritis; Interleukin-4 gene ( IL-4); Polymorphism; Interleukin-4 gene (IL-4)

Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular in...