Brownian dynamics simulations of the interactions between lactate dehydrogenase (LDH) and G- or F-Actin. Part I: Muscle and heart homo-isoforms

• Published in: Scientific African Vol. 9; p. e00510
• Main Authors: Njabon, Eric N., Patouossa, Issofa, Carlson, Kristine L., Lowe, Stephen L., Forlemu, Neville Y., Thomasson, Kathryn A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2020; Elsevier
• Subjects: Brownian dynamics; Electrostatic interactions; Free energy; Glycolytic enzymes; Protein-protein interactions; BD; Brownian dynamics; LDH-H4; PMF; Electrostatic interactions; LDH-M4; EP; COMs; Free energy; Protein-protein interactions; LDH; aldolase; GAPDH; Glycolytic enzymes

Glycolytic enzymes may compartment in cells by binding to cytoskeletal structures. One potentially important step in compartmentation is the binding of the cytoskeletal protein F-actin by lactate dehydrogenase (LDH). Brownian dynamics (BD) simulations of LDH interacting with G- or F-actin provided f...