Casein phosphopeptides and CaCl2 increase penicillin production and cause an increment in microbody/peroxisome proteins in Penicillium chrysogenum

• Published in: Journal of proteomics Vol. 156; pp. 52 - 62
• Main Authors: Domínguez-Santos, Rebeca, Kosalková, Katarina, García-Estrada, Carlos, Barreiro, Carlos, Ibáñez, Ana, Morales, Alejandro, Martín, Juan-Francisco
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 06.03.2017
• Subjects: amino acids; biosynthesis; Calcium; calcium chloride; casein; Casein phosphopeptides; catalase; fungi; genes; Microbodies; Penicillin; penicillins; Penicillium chrysogenum; Penicillium rubens; peroxisomes; phosphopeptides; proteomics; secretion; transaminases; Casein phosphopeptides; Penicillium rubens; Microbodies; Calcium; Penicillin; Penicillium chrysogenum

Transport of penicillin intermediates and penicillin secretion are still poorly characterized in Penicillium chrysogenum (re-identified as Penicillium rubens). Calcium (Ca2+) plays an important role in the metabolism of filamentous fungi, and casein phosphopeptides (CPP) are involved in Ca2+ interna...