Prognostic value of mixed lineage kinase domain-like protein expression in the survival of patients with gastric caner
The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and to analyze its association with the prognosis of GC patients. Immunohistochemical staining, Western blotting, and quantitative reverse-transcriptase polymerase chain reaction wer...
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Published in | Tumor biology Vol. 37; no. 10; pp. 13679 - 13685 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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01.10.2016
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Abstract | The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and to analyze its association with the prognosis of GC patients. Immunohistochemical staining, Western blotting, and quantitative reverse-transcriptase polymerase chain reaction were performed to detect MLKL tissue expression in 117 GC patients. Clinicopathological characteristics and survival data were retrospectively analyzed to discover the clinical importance of MLKL expression. The chi-square test was used to analyze the relationship between MLKL expression and the clinicopathological characteristics. Survival curves were plotted by using the Kaplan–Meier method and compared using the log-rank test. Survival data were evaluated using univariate and multivariate Cox regression analyses. The expression of MLKL mRNA was significantly higher in adjacent normal samples than in the tumor tissues (
P
= 0.003). Clinicopathological analysis showed that MLKL expression was significantly correlated with age (
P
= 0.013), histologic type (
P
= 0.049), differentiation grade (
P
< 0.001), depth of invasion (
P
= 0.022), and lymph node metastasis (
P
= 0.003). Low MLKL expression was significantly associated with decreased overall survival (median 29 months vs. 56 months,
P
< 0.001). Multivariate analysis suggested that MLKL expression might be an independent prognostic indicator (HR = 0.645, 95 % CI, 0.446–1.165,
P
= 0.002) for GC patients. In conclusion, our findings provide evidence that MLKL might serve as a candidate tumor suppressor and a potential prognostic biomarker for GC. |
---|---|
AbstractList | The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and to analyze its association with the prognosis of GC patients. Immunohistochemical staining, Western blotting, and quantitative reverse-transcriptase polymerase chain reaction were performed to detect MLKL tissue expression in 117 GC patients. Clinicopathological characteristics and survival data were retrospectively analyzed to discover the clinical importance of MLKL expression. The chi-square test was used to analyze the relationship between MLKL expression and the clinicopathological characteristics. Survival curves were plotted by using the Kaplan–Meier method and compared using the log-rank test. Survival data were evaluated using univariate and multivariate Cox regression analyses. The expression of MLKL mRNA was significantly higher in adjacent normal samples than in the tumor tissues (
P
= 0.003). Clinicopathological analysis showed that MLKL expression was significantly correlated with age (
P
= 0.013), histologic type (
P
= 0.049), differentiation grade (
P
< 0.001), depth of invasion (
P
= 0.022), and lymph node metastasis (
P
= 0.003). Low MLKL expression was significantly associated with decreased overall survival (median 29 months vs. 56 months,
P
< 0.001). Multivariate analysis suggested that MLKL expression might be an independent prognostic indicator (HR = 0.645, 95 % CI, 0.446–1.165,
P
= 0.002) for GC patients. In conclusion, our findings provide evidence that MLKL might serve as a candidate tumor suppressor and a potential prognostic biomarker for GC. The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and to analyze its association with the prognosis of GC patients. Immunohistochemical staining, Western blotting, and quantitative reverse-transcriptase polymerase chain reaction were performed to detect MLKL tissue expression in 117 GC patients. Clinicopathological characteristics and survival data were retrospectively analyzed to discover the clinical importance of MLKL expression. The chi-square test was used to analyze the relationship between MLKL expression and the clinicopathological characteristics. Survival curves were plotted by using the Kaplan-Meier method and compared using the log-rank test. Survival data were evaluated using univariate and multivariate Cox regression analyses. The expression of MLKL mRNA was significantly higher in adjacent normal samples than in the tumor tissues (P = 0.003). Clinicopathological analysis showed that MLKL expression was significantly correlated with age (P = 0.013), histologic type (P = 0.049), differentiation grade (P < 0.001), depth of invasion (P = 0.022), and lymph node metastasis (P = 0.003). Low MLKL expression was significantly associated with decreased overall survival (median 29 months vs. 56 months, P < 0.001). Multivariate analysis suggested that MLKL expression might be an independent prognostic indicator (HR = 0.645, 95 % CI, 0.446-1.165, P = 0.002) for GC patients. In conclusion, our findings provide evidence that MLKL might serve as a candidate tumor suppressor and a potential prognostic biomarker for GC. The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and to analyze its association with the prognosis of GC patients. Immunohistochemical staining, Western blotting, and quantitative reverse-transcriptase polymerase chain reaction were performed to detect MLKL tissue expression in 117 GC patients. Clinicopathological characteristics and survival data were retrospectively analyzed to discover the clinical importance of MLKL expression. The chi-square test was used to analyze the relationship between MLKL expression and the clinicopathological characteristics. Survival curves were plotted by using the Kaplan-Meier method and compared using the log-rank test. Survival data were evaluated using univariate and multivariate Cox regression analyses. The expression of MLKL mRNA was significantly higher in adjacent normal samples than in the tumor tissues (P = 0.003). Clinicopathological analysis showed that MLKL expression was significantly correlated with age (P = 0.013), histologic type (P = 0.049), differentiation grade (P < 0.001), depth of invasion (P = 0.022), and lymph node metastasis (P = 0.003). Low MLKL expression was significantly associated with decreased overall survival (median 29 months vs. 56 months, P < 0.001). Multivariate analysis suggested that MLKL expression might be an independent prognostic indicator (HR = 0.645, 95 % CI, 0.446-1.165, P = 0.002) for GC patients. In conclusion, our findings provide evidence that MLKL might serve as a candidate tumor suppressor and a potential prognostic biomarker for GC. |
Author | Kang, Wang Zhijun, Ye Changjiang, Qin Jianhui, Chen Chuangqi, Chen Shirong, Cai Ertao, Zhai Sile, Chen Hui, Wu Yulong, He |
Author_xml | – sequence: 1 givenname: Zhai surname: Ertao fullname: Ertao, Zhai organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 2 givenname: Chen surname: Jianhui fullname: Jianhui, Chen organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 3 givenname: Wang surname: Kang fullname: Kang, Wang organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 4 givenname: Ye surname: Zhijun fullname: Zhijun, Ye organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 5 givenname: Wu surname: Hui fullname: Hui, Wu email: Docwuhui@126.com organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 6 givenname: Chen surname: Chuangqi fullname: Chuangqi, Chen organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 7 givenname: Qin surname: Changjiang fullname: Changjiang, Qin organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 8 givenname: Chen surname: Sile fullname: Sile, Chen organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 9 givenname: He surname: Yulong fullname: Yulong, He organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University – sequence: 10 givenname: Cai surname: Shirong fullname: Shirong, Cai email: Caisrteam@163.com organization: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University |
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Snippet | The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and to analyze its association with the... |
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SubjectTerms | Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Female Follow-Up Studies Humans Immunoenzyme Techniques Male Middle Aged Neoplasm Grading Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Staging Original Article Prognosis Protein Kinases - genetics Protein Kinases - metabolism Real-Time Polymerase Chain Reaction Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Survival Rate |
Title | Prognostic value of mixed lineage kinase domain-like protein expression in the survival of patients with gastric caner |
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