Phase 1, Single‐ and Multiple‐Ascending‐Dose, Food‐Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase

• Published in: Clinical pharmacology in drug development Vol. 12; no. 10; pp. 1022 - 1035
• Main Authors: Amore, Benny M., MacDougall, Diane E., Hanselman, Jeffrey C., Emery, Maurice G.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2023
• Subjects: Acids; Adenosine triphosphate; Pharmacokinetics; clinical pharmacokinetics; East Asian; bempedoic acid; food effect; bioavailability

Bempedoic acid is an adenosine triphosphate citrate lyase inhibitor that lowers low‐density lipoprotein cholesterol by inhibiting cholesterol synthesis and upregulating hepatic low‐density lipoprotein receptor expression. After oral dosing, bempedoic acid was readily absorbed, attaining maximum conc...