Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial

• Published in: The American journal of gastroenterology Vol. 106; no. 3; pp. 508 - 514
• Main Authors: Biesiekierski, Jessica R, Newnham, Evan D, Irving, Peter M, Barrett, Jacqueline S, Haines, Melissa, Doecke, James D, Shepherd, Susan J, Muir, Jane G, Gibson, Peter R
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.03.2011; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Adult; Aged; Biological and medical sciences; Biomarkers - blood; Celiac disease; Celiac Disease - diagnosis; Colitis - chemically induced; Diet, Gluten-Free; Double-Blind Method; Enteritis - chemically induced; Female; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - immunology; Gastrointestinal Tract - physiopathology; Glutens - adverse effects; Glutens - immunology; Humans; Irritable Bowel Syndrome - immunology; Irritable Bowel Syndrome - physiopathology; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Treatment Outcome; Human; Immunopathology; Symptomatology; Intestinal malabsorption; Gastroenterology; Digestive diseases; Intestinal disease; Gastrointestinal; Coeliac disease; Gluten

Despite increased prescription of a gluten-free diet for gastrointestinal symptoms in individuals who do not have celiac disease, there is minimal evidence that suggests that gluten is a trigger. The aims of this study were to determine whether gluten ingestion can induce symptoms in non-celiac indi...