Glucocorticoid effects on somatomedins and somatomedin inhibitors

• Published in: The journal of clinical endocrinology and metabolism Vol. 61; no. 4; p. 618
• Main Authors: Unterman, T G, Phillips, L S
• Format: Journal Article
• Language: English
• Published: United States 01.10.1985
• Subjects: Adolescent; Adult; Animals; Biological Assay; Cartilage - growth & development; Cartilage - metabolism; Child; Cushing Syndrome - blood; Female; Glucocorticoids - administration & dosage; Glucocorticoids - pharmacology; Humans; Hydrocortisone - pharmacology; In Vitro Techniques; Male; Middle Aged; Prednisone - pharmacology; Rats; Somatomedins - blood; Sulfates - metabolism; Swine; Thymidine - metabolism; Uridine - metabolism

Glucocorticoid excess may be associated with poor growth despite normal levels of GH and adequate nutrition. Steroid-induced growth failure could be mediated by defective generation and/or action of somatomedins. To probe potential mechanisms, we examined the effect of corticosteroid administration...