Plasma Human Cartilage Glycoprotein‐39 and Cognitive Impairment After Acute Ischemic Stroke

• Published in: Journal of the American Heart Association Vol. 14; no. 2; p. e036790
• Main Authors: Wang, Ziyi, Zhang, Kaixin, Zhong, Chongke, Zhu, Zhengbao, Zheng, Xiaowei, Yang, Pinni, Che, Bizhong, Lu, Yaling, Zhang, Yonghong, Xu, Tian
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 21.01.2025; Wiley
• Subjects: Aged; biomarkers; Biomarkers - blood; China - epidemiology; Chitinase-3-Like Protein 1 - blood; Cognitive Dysfunction - blood; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - epidemiology; Cognitive Dysfunction - etiology; cognitive impairment; Female; Humans; ischemic stroke; Ischemic Stroke - blood; Ischemic Stroke - complications; Ischemic Stroke - diagnosis; Ischemic Stroke - psychology; Male; Mental Status and Dementia Tests; Middle Aged; Original Research; prognosis; Risk Factors; Time Factors; YKL‐40; China; YKL‐40; cognitive impairment; prognosis; biomarkers; ischemic stroke
• DOI: 10.1161/JAHA.124.036790
• ISSN: 2047-9980

Our study aimed at evaluating the association between plasma human cartilage glycoprotein-39 (YKL-40) and cognitive impairment at 3 months among patients with acute ischemic stroke. Plasma YKL-40 levels were measured in 604 participants from the China Antihypertensive Trial in Acute Ischemic Stroke. Cognitive impairment outcomes were assessed at 3 months poststroke using the Mini-Mental State Examination and the Montreal Cognitive Assessment. According to the Mini-Mental State Examination score, patients in the highest quartile of YKL-40 had a 2.01-fold (95% CI, 1.23-3.29; for trend=0.009) risk of poststroke cognitive impairment compared with those in the lowest quartile. Each 1 SD difference of logarithm-transformed YKL-40 was associated with a 28% (95% CI, 7-53) increased risk for the outcome. The multiple-adjusted spline regression model confirmed dose-response relationships between YKL-40 and poststroke cognitive impairment ( for linearity=0.01). Adding YKL-40 to a model containing conventional risk factors significantly improved the discriminatory power (area under the receiver operating characteristic curve improved by 0.02, =0.03). When cognitive impairment was defined using the Montreal Cognitive Assessment score, similar findings were observed. Elevated YKL-40 levels were associated with an increased risk of cognitive impairment at 3 months among patients with acute ischemic stroke. URL: clinicaltrials.gov; Unique Identifier: NCT01840072.