Establishment of an induced pluripotent stem cell line SDQLCHi048-A from a healthy boy donor

The induced pluripotent stem cells (iPSCs) line was generated using peripheral blood mononuclear cells (PBMCs) from a healthy 1-month-old boy. Expression of pluripotency markers, deletion of free episomal vectors, preservation of normal karyotype, and potential for in vitro trilineage differentiatio...

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Published inStem cell research Vol. 69; p. 103115
Main Authors Feng, Ziwen, Yang, Xiaomeng, Guan, Jingyun, Song, Wei, Liu, Yi
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.06.2023
Elsevier
Subjects
Cell Differentiation
Cell Line
Humans
Induced Pluripotent Stem Cells - metabolism
Infant
Kruppel-Like Factor 4
Leukocytes, Mononuclear - metabolism
Male
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Summary:The induced pluripotent stem cells (iPSCs) line was generated using peripheral blood mononuclear cells (PBMCs) from a healthy 1-month-old boy. Expression of pluripotency markers, deletion of free episomal vectors, preservation of normal karyotype, and potential for in vitro trilineage differentiation were demonstrated in the iPSCs line SDQLCHi048-A. This cell line may serve as a basis for disease modeling and help to further explore the molecular pathogenesis.
Bibliography:ObjectType-Article-1
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ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2023.103115