Oxidative Deamination of Methylamine by Semicarbazide-Sensitive Amine Oxidase Leads to Cytotoxic Damage in Endothelial Cells: Possible Consequences for Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 42; no. 4; pp. 594 - 603
• Main Authors: Yu, Peter H, Zuo, Dong-Mei
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.04.1993
• Subjects: Amine Oxidase (Copper-Containing) - metabolism; Animals; Benzylamines - metabolism; Benzylamines - pharmacology; Cardiovascular diseases; Cell Line; Cell Survival - drug effects; Cells, Cultured; Complications and side effects; Deamination; Development and progression; Diabetes; Diabetes mellitus; Diabetes Mellitus - physiopathology; Dose-Response Relationship, Drug; Endothelium; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Formaldehyde - pharmacology; Humans; Hydrogen Peroxide - pharmacology; Injuries; Male; Methylamines - metabolism; Methylamines - pharmacology; Oxidases; Oxidation-Reduction; Physiological aspects; Rats; Rats, Wistar; Substrate Specificity; Umbilical Arteries

Methylamine was observed to be deaminated by several semicarbazide-sensitive amine oxidases, which were prepared from blood and vascular tissues of various species, including humans. Although methylamine itself is relatively nontoxic toward endothelial cells obtained from both human umbilical vein a...