Human induced pluripotent stem cells (NIHTVBi029-A and NIHTVBi030-A) generated from two patients with a heterozygous mutation in the CDC42 gene

• Published in: Stem cell research Vol. 80; p. 103517
• Main Authors: Varea, Isabella, Joseph, Benjamin, Emmerich, Kevin, Manohar-Sindhu, Sahana, Zou, Jizhong, Friend, Kip, Tang, Xuming, Yang, Dan, de Jesus Rasheed, Adriana A, Goldbach-Mansky, Raphaela, Boehm, Manfred
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.10.2024; Elsevier
• Subjects: Adolescent; cdc42 GTP-Binding Protein - genetics; cdc42 GTP-Binding Protein - metabolism; Cell Differentiation; Child; Female; Heterozygote; Humans; Induced Pluripotent Stem Cells - metabolism; Male; Mutation

Induced pluripotent stem cells (iPSCs) were successfully generated from peripheral blood mononuclear cells obtained from two patients with a heterozygous mutation in the CDC42 gene. Both iPSC lines expressed pluripotency markers, differentiated into the three germ layers in vitro, showed normal kary...