Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

• Published in: Journal of cell science Vol. 115; no. Pt 1; pp. 39 - 50
• Main Authors: Gudjonsson, Thorarinn, Rønnov-Jessen, Lone, Villadsen, René, Rank, Fritz, Bissell, Mina J, Petersen, Ole William
• Format: Journal Article
• Language: English
• Published: England 01.01.2002
• Subjects: Basement Membrane - metabolism; Biomarkers - analysis; Breast - cytology; Breast - metabolism; Breast - physiology; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Carcinoma, Intraductal, Noninfiltrating - metabolism; Carcinoma, Intraductal, Noninfiltrating - pathology; Cell Differentiation; Cell Polarity - physiology; Collagen - physiology; Epithelial Cells - metabolism; Epithelial Cells - physiology; Extracellular Matrix - chemistry; Extracellular Matrix - physiology; Female; Fluorescent Antibody Technique; Gels - chemistry; Humans; Immunohistochemistry; Laminin - biosynthesis; Laminin - immunology; Microscopy, Confocal; Tumor Cells, Cultured

The signals that determine the correct polarity of breast epithelial structures in vivo are not understood. We have shown previously that luminal epithelial cells can be polarized when cultured within a reconstituted basement membrane gel. We reasoned that such cues in vivo may be given by myoepithe...