Sequence-Selective DNA Recognition: Natural Products and Nature’s Lessons

Biologically active, therapeutically useful, DNA binding natural products continue to reveal new paradigms for sequence-selective recognition, to enlist beautiful mechanisms of in situ activation for DNA modification, to define new therapeutic targets, to exploit new mechanisms to achieve cellular s...

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Bibliographic Details
Published inChemistry & biology Vol. 11; no. 12; pp. 1607 - 1617
Main Authors Tse, Winston C., Boger, Dale L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.12.2004
Subjects
Animals
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
DNA - chemistry
DNA - drug effects
DNA - metabolism
Humans
Models, Molecular
Molecular Conformation
Protein Binding - drug effects
Stereoisomerism
Structure-Activity Relationship
Substrate Specificity
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Summary:Biologically active, therapeutically useful, DNA binding natural products continue to reveal new paradigms for sequence-selective recognition, to enlist beautiful mechanisms of in situ activation for DNA modification, to define new therapeutic targets, to exploit new mechanisms to achieve cellular selectivity, and to provide a rich source of new drugs. These attributes arise in compact structures of complex integrated function.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1074-5521
1879-1301
DOI:10.1016/j.chembiol.2003.08.012