Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects

• Published in: British journal of nutrition Vol. 89; no. 5; pp. 679 - 689
• Main Authors: Wallace, Fiona A., Miles, Elizabeth A., Calder, Philip C.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.05.2003
• Subjects: administration & dosage; Adolescent; Adult; alpha-Linolenic Acid; alpha-Linolenic Acid - administration & dosage; alpha-Tocopherol; alpha-Tocopherol - blood; analysis; Analysis of Variance; antioxidant activity; Biological and medical sciences; biosynthesis; blood; blood lipids; Cell Division; chemistry; Cytokine; Cytokines; Cytokines - biosynthesis; dietary fat; dietary supplements; docosahexaenoic acid; Docosahexaenoic Acids; Docosahexaenoic Acids - administration & dosage; dose response; Double-Blind Method; Drug Administration Schedule; drug effects; eicosapentaenoic acid; Eicosapentaenoic Acid - administration & dosage; experimental diets; fatty acid composition; Fatty Acids; Fatty Acids - blood; Feeding. Feeding behavior; Fish oil; Fish oils; Fish Oils - administration & dosage; Fundamental and applied biological sciences. Psychology; human nutrition; Humans; Immune response; Immunity; immunology; interferons; Interleukin-6; Interleukin-6 - immunology; interleukins; Leukocytes, Mononuclear; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; linolenic acid; Linseed oil; Lymphocyte; lymphocyte proliferation; Lymphocytes; Male; men; Monocyte; monocytes; n-3 Polyunsaturated fatty acids; nutrient intake; omega-3 fatty acids; phospholipids; Phospholipids - chemistry; Polyunsaturated fatty acids; T-Lymphocyte Subsets; T-Lymphocyte Subsets - immunology; Thiobarbituric Acid Reactive Substances; Thiobarbituric Acid Reactive Substances - analysis; tumor necrosis factors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; α-Linolenic acid; Monocyte; n-3 Polyunsaturated fatty acids; Linseed oil; Cytokine; Fish oil; α-Linolenic acid; Immunity; Lymphocyte; Human; Cell function; Polyunsaturated fatty acid; Dose activity relation; Linolenic acid; Mononuclear cell; Comparative study; Immune system

Studies on animal and human subjects have shown that greatly increasing the amount of linseed (also known as flaxseed) oil (rich in the n−3 polyunsaturated fatty acid (PUFA) α-linolenic acid (ALNA)) or fish oil (FO; rich in the long-chain n−3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid...