The effects of circadian disturbances induced by night shifts on the mouse peripheral tissues

We have examined the effect of circadian disturbances induced by night shifts (NSs) on the phenotypes of the tibiae and abdominal adipose tissues (ADTs) in a mouse model by using in vivo micro-computed tomography (micro-CT). We found that the volumes of total and visceral ADTs in the night-shifted g...

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Published inAnimal cells and systems Vol. 16; no. 5; pp. 357 - 365
Main Authors Seo, Dong-Hyun, Kim, Han-Sung, Ko, Chang-Yong, Schreiber, Jürgen, Jang, Yeong-Su, Bae, Kiho
Format Journal Article
LanguageEnglish
Published Daejeon Taylor & Francis Group 01.10.2012
Taylor & Francis Ltd
한국통합생물학회
Subjects
Adipose tissue
adipose tissues
Bone mineral density
circadian rhythm
Circadian rhythms
Computed tomography
in vivo micro-CT
tibiae
생물학
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ISSN1976-8354
2151-2485
DOI10.1080/19768354.2012.706639

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Abstract We have examined the effect of circadian disturbances induced by night shifts (NSs) on the phenotypes of the tibiae and abdominal adipose tissues (ADTs) in a mouse model by using in vivo micro-computed tomography (micro-CT). We found that the volumes of total and visceral ADTs in the night-shifted group of mice were significantly larger (69 and 92%, respectively) than those in the control. The mean polar moment of inertia, cross-sectional thickness, and bone mineral density of the cortical bone in the night-shifted group of mice were less (13, 5, and 3%, respectively) than those in the control. Moreover, the volume and the thickness of growth plates (GPs) of the tibiae in the night-shifted mice were significantly smaller (22 and 20%, respectively) than those in the control. Taken together, our results indicate that disturbances in the mouse circadian rhythms induced by NSs affect the morphological characteristics of cortical bone, the volume and the thickness of GPs, and the volume of ADTs.
AbstractList We have examined the effect of circadian disturbances induced by night shifts (NSs) on the phenotypes of the tibiae and abdominal adipose tissues (ADTs) in a mouse model by using in vivo micro-computed tomography (micro-CT). We found that the volumes of total and visceral ADTs in the night-shifted group of mice were significantly larger (69 and 92%, respectively) than those in the control. The mean polar moment of inertia, cross-sectional thickness, and bone mineral density of the cortical bone in the night-shifted group of mice were less (13, 5, and 3%, respectively) than those in the control. Moreover, the volume and the thickness of growth plates (GPs) of the tibiae in the night-shifted mice were significantly smaller (22 and 20%, respectively) than those in the control. Taken together, our results indicate that disturbances in the mouse circadian rhythms induced by NSs affect the morphological characteristics of cortical bone, the volume and the thickness of GPs, and the volume of ADTs. [PUBLICATION ABSTRACT]
We have examined the effect of circadian disturbances induced by night shifts (NSs) on the phenotypes of the tibiae and abdominal adipose tissues (ADTs) in a mouse model by using in vivo micro-computed tomography (micro-CT). We found that the volumes of total and visceral ADTs in the night-shifted group of mice were significantly larger (69 and 92%, respectively) than those in the control. The mean polar moment of inertia, cross-sectional thickness,and bone mineral density of the cortical bone in the night-shifted group of mice were less (13, 5, and 3%, respectively)than those in the control. Moreover, the volume and the thickness of growth plates (GPs) of the tibiae in the nightshifted mice were significantly smaller (22 and 20%, respectively) than those in the control. Taken together, our results indicate that disturbances in the mouse circadian rhythms induced by NSs affect the morphological characteristics of cortical bone, the volume and the thickness of GPs, and the volume of ADTs. KCI Citation Count: 2
We have examined the effect of circadian disturbances induced by night shifts (NSs) on the phenotypes of the tibiae and abdominal adipose tissues (ADTs) in a mouse model by using in vivo micro-computed tomography (micro-CT). We found that the volumes of total and visceral ADTs in the night-shifted group of mice were significantly larger (69 and 92%, respectively) than those in the control. The mean polar moment of inertia, cross-sectional thickness, and bone mineral density of the cortical bone in the night-shifted group of mice were less (13, 5, and 3%, respectively) than those in the control. Moreover, the volume and the thickness of growth plates (GPs) of the tibiae in the night-shifted mice were significantly smaller (22 and 20%, respectively) than those in the control. Taken together, our results indicate that disturbances in the mouse circadian rhythms induced by NSs affect the morphological characteristics of cortical bone, the volume and the thickness of GPs, and the volume of ADTs.
Author Seo, Dong-Hyun
Bae, Kiho
Kim, Han-Sung
Ko, Chang-Yong
Jang, Yeong-Su
Schreiber, Jürgen
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SubjectTerms Adipose tissue
adipose tissues
Bone mineral density
circadian rhythm
Circadian rhythms
Computed tomography
in vivo micro-CT
tibiae
생물학
Title The effects of circadian disturbances induced by night shifts on the mouse peripheral tissues
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