ALK rearranged non–small cell lung carcinoma with EML4-NTRK3 fusion as a possible mechanism of resistance to third-generation ALK inhibitors

• Published in: Current problems in cancer. Case reports Vol. 4; p. 100124
• Main Authors: Corral de la Fuente, Elena, Benito Berlinches, Amparo, Gomez Rueda, Ana, Olmedo García, María Eugenia, Lage Alfranca, Yolanda, Lario, Margaret, Santón Roldán, Almudena, Garrido, Pilar
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2021; Elsevier
• Subjects: ALK fusion; ALK TKI resistance; Next generation sequencing; Non-small cell lung cancer; NTRK3 fusion; Next generation sequencing; NTRK3 fusion; Non-small cell lung cancer; ALK TKI resistance; ALK fusion

•Echinoderm microtubule associated protein-like 4 (EML4)- anaplastic lymphoma kinase (ALK) fusion is the most common in NonSmall Cell Lung Cancer (NSCLC). Fluorescence in situ hybridization (FISH) has been regarded as the gold standard method for detecting ALK rearrangement. However, FISH is not abl...