Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages

• Published in: Food and agricultural immunology Vol. 33; no. 1; pp. 47 - 64
• Main Authors: Hsieh, Wen-Che, Lai, Chane-Yu, Lin, Hui-Wen, Tu, Dom-Gene, Shen, Ting-Jing, Lee, Yi-Ju, Hsieh, Ming-Chang, Chen, Ching-Chung, Han, Hsin-Hsuan, Chang, Yuan-Yen
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 31.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Alveoli; Ambient fine particulate matter (PM2.5); chemokine CCL5; Exposure; Flavonoids; HO-1; Inflammation; Inflammatory response; Interleukin 6; JAK/STAT/NF-κB; Janus kinase 2; lungs; luteolin; Macrophages; mice; Monocyte chemoattractant protein 1; murine alveolar macrophages; NF-κB protein; Nitric-oxide synthase; Particulate matter; Plant species; Pretreatment; Proteins; RANTES; Stat1 protein; Stat3 protein; Tumor necrosis factor-α

To explore the involved mechanisms and possible treatments of ambient PM2.5 exposure-induced lung inflammation, this work studied the activity of luteolin, a natural flavonoid which widely presents in many plant species, in murine alveolar macrophage MH S cells exposed to PM2.5. Results showed PM2.5...