Mouse Models of Frailty: an Emerging Field

• Published in: Current osteoporosis reports Vol. 13; no. 5; pp. 280 - 286
• Main Authors: Seldeen, K. L., Pang, M., Troen, B. R.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2015
• Subjects: Aged; Aging; Animals; Epidemiology; Frail Elderly; Humans; Medicine; Medicine & Public Health; Mice; Models, Animal; Muscle and Bone (L Bonewald and M Hamrick; Muscle Strength; Orthopedics; Physical Endurance; Section Editors; Topical Collection on Muscle and Bone; Frailty; Deficit accumulation; Mice; Animals; Physical performance; Behavioral assessments

Frailty is highly prevalent in the elderly, increasing the risk of poor outcomes that include falls, incident disability, hospitalization, and mortality. Thus, a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent, delay, and even reverse frail...