Promoter methylation and increased expression of PD-L1 in patients with active tuberculosis

• Published in: Microbial cell Vol. 11; p. 278
• Main Authors: Tseng, Yen-Han, Pan, Sheng-Wei, Huang, Jhong-Ru, Lee, Chang-Ching, Hung, Jung-Jyh, Hsu, Po-Kuei, Chen, Nien-Jung, Su, Wei-Juin, Chen, Yuh-Min, Feng, Jia-Yih
• Format: Journal Article
• Language: English
• Published: Austria Shared Science Publishers 01.01.2024; Shared Science Publishers OG
• Subjects: macrophages; methylation; pd-l1; pulmonary tuberculosis; treatment outcomes; pulmonary tuberculosis; PD-L1; macrophages; treatment outcomes; methylation

The PD-1/PD-L1 pathway plays a pivotal role in T cell activity and is involved in the pathophysiology of Mycobacterium tuberculosis (MTB) infection. DNA methylation is a mechanism that modulates PD-L1 expression in cancer cells. However, its effect on PD-L1 expression in macrophages after MTB infect...