Clinical utility of simultaneous measurement of alpha-fetoprotein and des-γ-carboxy prothrombin for diagnosis of patients with hepatocellular carcinoma in China: A multi-center case-controlled study of 1,153 subjects

• Published in: BioScience Trends Vol. 8; no. 5; pp. 266 - 273
• Main Authors: Zheng, Shuguo, Sugawara, Yasuhiko, Zhang, Keming, Hasegawa, Kiyoshi, Li, Qiang, Kokudo, Norihiro, Feng, Xiaobin, Ma, Kuansheng, Song, Tianqiang, Inagaki, Yoshinori, Zhao, Xin, Wang, Zhigang, Kong, Dalu, Song, Peipei, Wu, Qiang, Zhang, Ti, Tang, Wei, Japan-China Joint Team for Medical Research and Cooperation on HCC
• Format: Journal Article
• Language: English
• Published: Japan International Research and Cooperation Association for Bio & Socio-Sciences Advancement 01.10.2014
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; alpha-fetoprotein (AFP); alpha-Fetoproteins - metabolism; Biomarkers - blood; Biomarkers, Tumor - blood; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - pathology; Case-Control Studies; Child; China; des-γ-carboxy prothrombin (DCP); Female; Humans; Liver Neoplasms - blood; Liver Neoplasms - diagnosis; Liver Neoplasms - pathology; Male; Middle Aged; Protein Precursors - blood; Prothrombin; ROC Curve; sensitivity; Sensitivity and Specificity; Serum biomarker; specificity; China

This study aimed to investigate the clinical utility of simultaneous measurement of alphafetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) for hepatocellular carcinoma (HCC) diagnosis in Chinese patients predominantly caused by hepatitis B virus infection by a multi-center case-controlled study....