Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations

• Published in: Cancer prevention research (Philadelphia, Pa.) Vol. 13; no. 4; pp. 357 - 366
• Main Authors: Chen, Kun-Ming, Sun, Yuan-Wan, Kawasawa, Yuka Imamura, Salzberg, Anna C, Zhu, Junjia, Gowda, Krishne, Aliaga, Cesar, Amin, Shantu, Atkins, Hannah, El-Bayoumy, Karam
• Format: Journal Article
• Language: English
• Published: United States 01.04.2020

We previously reported that the environmental pollutant and tobacco smoke constituent dibenzo[ ]chrysene (DBP) induced DNA damage, altered DNA methylation and induced oral squamous cell carcinoma (OSCC) in mice. In the present study, we showed that 5% dietary black raspberry (BRB) significantly redu...