hiPSC-derived GRN-deficient astrocytes delay spiking activity of developing neurons

• Published in: Neurobiology of disease Vol. 181; p. 106124
• Main Authors: Lee, Christopher, Frew, Jonathan, Weilinger, Nicholas L., Wendt, Stefan, Cai, Wenji, Sorrentino, Stefano, Wu, Xiujuan, MacVicar, Brian A., Willerth, Stephanie M., Nygaard, Haakon B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2023; Elsevier
• Subjects: Astrocytes; Astrocytes - metabolism; Frontotemporal dementia; Frontotemporal Dementia - pathology; hiPSC; Humans; Induced Pluripotent Stem Cells - metabolism; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Multielectrode array; Mutation; Neuronal spiking; Neurons; Neurons - metabolism; Pick Disease of the Brain - metabolism; Progranulin; Progranulins - genetics; Neuronal spiking; Progranulin; Multielectrode array; hiPSC; Astrocytes; Neurons; Frontotemporal dementia

Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders that are characterized by pathology predominantly localized to the frontal and temporal lobes. Approximately 40% of FTD cases are familial, and up to 20% of these are caused by heterozygous loss of function mutations in t...