Forkhead box O1 transcription factor; a therapeutic target for diabetic cardiomyopathy

• Published in: Journal of pharmacy & pharmaceutical sciences Vol. 27; p. 13193
• Main Authors: Shafaati, Tanin, Gopal, Keshav
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.08.2024
• Subjects: Animals; cell death; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetic Cardiomyopathies - drug therapy; Diabetic Cardiomyopathies - metabolism; diabetic cardiomyopathy; energy metabolism; Forkhead Box Protein O1 - metabolism; Forkhead Transcription Factors - antagonists & inhibitors; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; FoxO1; Humans; oxidative stress; Oxidative Stress - drug effects; Science archive; diabetic cardiomyopathy; cell death; energy metabolism; oxidative stress; FoxO1

Cardiovascular disease including diabetic cardiomyopathy (DbCM) represents the leading cause of death in people with diabetes. DbCM is defined as ventricular dysfunction in the absence of underlying vascular diseases and/or hypertension. The known molecular mediators of DbCM are multifactorial, incl...