Forkhead box O1 transcription factor; a therapeutic target for diabetic cardiomyopathy
Cardiovascular disease including diabetic cardiomyopathy (DbCM) represents the leading cause of death in people with diabetes. DbCM is defined as ventricular dysfunction in the absence of underlying vascular diseases and/or hypertension. The known molecular mediators of DbCM are multifactorial, incl...
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| Published in | Journal of pharmacy & pharmaceutical sciences Vol. 27; p. 13193 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
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14.08.2024
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| Abstract | Cardiovascular disease including diabetic cardiomyopathy (DbCM) represents the leading cause of death in people with diabetes. DbCM is defined as ventricular dysfunction in the absence of underlying vascular diseases and/or hypertension. The known molecular mediators of DbCM are multifactorial, including but not limited to insulin resistance, altered energy metabolism, lipotoxicity, endothelial dysfunction, oxidative stress, apoptosis, and autophagy. FoxO1, a prominent member of forkhead box O transcription factors, is involved in regulating various cellular processes in different tissues. Altered FoxO1 expression and activity have been associated with cardiovascular diseases in diabetic subjects. Herein we provide an overview of the role of FoxO1 in various molecular mediators related to DbCM, such as altered energy metabolism, lipotoxicity, oxidative stress, and cell death. Furthermore, we provide valuable insights into its therapeutic potential by targeting these perturbations to alleviate cardiomyopathy in settings of type 1 and type 2 diabetes. |
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| AbstractList | Cardiovascular disease including diabetic cardiomyopathy (DbCM) represents the leading cause of death in people with diabetes. DbCM is defined as ventricular dysfunction in the absence of underlying vascular diseases and/or hypertension. The known molecular mediators of DbCM are multifactorial, including but not limited to insulin resistance, altered energy metabolism, lipotoxicity, endothelial dysfunction, oxidative stress, apoptosis, and autophagy. FoxO1, a prominent member of forkhead box O transcription factors, is involved in regulating various cellular processes in different tissues. Altered FoxO1 expression and activity have been associated with cardiovascular diseases in diabetic subjects. Herein we provide an overview of the role of FoxO1 in various molecular mediators related to DbCM, such as altered energy metabolism, lipotoxicity, oxidative stress, and cell death. Furthermore, we provide valuable insights into its therapeutic potential by targeting these perturbations to alleviate cardiomyopathy in settings of type 1 and type 2 diabetes. Cardiovascular disease including diabetic cardiomyopathy (DbCM) represents the leading cause of death in people with diabetes. DbCM is defined as ventricular dysfunction in the absence of underlying vascular diseases and/or hypertension. The known molecular mediators of DbCM are multifactorial, including but not limited to insulin resistance, altered energy metabolism, lipotoxicity, endothelial dysfunction, oxidative stress, apoptosis, and autophagy. FoxO1, a prominent member of forkhead box O transcription factors, is involved in regulating various cellular processes in different tissues. Altered FoxO1 expression and activity have been associated with cardiovascular diseases in diabetic subjects. Herein we provide an overview of the role of FoxO1 in various molecular mediators related to DbCM, such as altered energy metabolism, lipotoxicity, oxidative stress, and cell death. Furthermore, we provide valuable insights into its therapeutic potential by targeting these perturbations to alleviate cardiomyopathy in settings of type 1 and type 2 diabetes.Cardiovascular disease including diabetic cardiomyopathy (DbCM) represents the leading cause of death in people with diabetes. DbCM is defined as ventricular dysfunction in the absence of underlying vascular diseases and/or hypertension. The known molecular mediators of DbCM are multifactorial, including but not limited to insulin resistance, altered energy metabolism, lipotoxicity, endothelial dysfunction, oxidative stress, apoptosis, and autophagy. FoxO1, a prominent member of forkhead box O transcription factors, is involved in regulating various cellular processes in different tissues. Altered FoxO1 expression and activity have been associated with cardiovascular diseases in diabetic subjects. Herein we provide an overview of the role of FoxO1 in various molecular mediators related to DbCM, such as altered energy metabolism, lipotoxicity, oxidative stress, and cell death. Furthermore, we provide valuable insights into its therapeutic potential by targeting these perturbations to alleviate cardiomyopathy in settings of type 1 and type 2 diabetes. |
| Author | Gopal, Keshav Shafaati, Tanin |
| AuthorAffiliation | 3 Cardiovascular Research Institute , University of Alberta , Edmonton , AB , Canada 1 Faculty of Pharmacy and Pharmaceutical Sciences , University of Alberta , Edmonton , AB , Canada 2 Alberta Diabetes Institute , University of Alberta , Edmonton , AB , Canada |
| AuthorAffiliation_xml | – name: 1 Faculty of Pharmacy and Pharmaceutical Sciences , University of Alberta , Edmonton , AB , Canada – name: 2 Alberta Diabetes Institute , University of Alberta , Edmonton , AB , Canada – name: 3 Cardiovascular Research Institute , University of Alberta , Edmonton , AB , Canada |
| Author_xml | – sequence: 1 givenname: Tanin surname: Shafaati fullname: Shafaati, Tanin – sequence: 2 givenname: Keshav surname: Gopal fullname: Gopal, Keshav |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39206323$$D View this record in MEDLINE/PubMed |
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| Keywords | diabetic cardiomyopathy cell death energy metabolism oxidative stress FoxO1 |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Sherif Hanafy Mahmoud, University of Alberta, Canada ORCID: Tanin Shafaati, https://orcid.org/0009-0000-9643-9429 |
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| SubjectTerms | Animals cell death Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetic Cardiomyopathies - drug therapy Diabetic Cardiomyopathies - metabolism diabetic cardiomyopathy energy metabolism Forkhead Box Protein O1 - metabolism Forkhead Transcription Factors - antagonists & inhibitors Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FoxO1 Humans oxidative stress Oxidative Stress - drug effects Science archive |
| Title | Forkhead box O1 transcription factor; a therapeutic target for diabetic cardiomyopathy |
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