Molecular organization of hydrophobic molecules and co-adsorbed water in SBA-15 ordered mesoporous silica material

The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material. Understanding this adsorption competition is essential in the development of applications of...

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Published inPhysical chemistry chemical physics : PCCP Vol. 13; no. 7; pp. 2706 - 2713
Main Authors MELLAERTS, Randy, ROEFFAERS, Maarten B. J, HOUTHOOFD, Kristof, VAN SPEYBROECK, Michiel, DE CREMER, Gert, JAMMAER, Jasper A. G, VAN DEN MOOTER, Guy, AUGUSTIJNS, Patrick, HOFKENS, Johan, MARTENS, Johan A
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 01.01.2011
Subjects
Adsorption
Agglomeration
Chemistry
Colloidal state and disperse state
Confocal
Drugs
Exact sciences and technology
Fluorescence
General and physical chemistry
Hydrophobic and Hydrophilic Interactions
Itraconazole - chemistry
Magnetic Resonance Spectroscopy
Migration
Organizations
Oxazines - chemistry
Porosity
Porous materials
Silicon dioxide
Silicon Dioxide - chemistry
Spectroscopy, Fourier Transform Infrared
Surface physical chemistry
Water - chemistry
Water
Binary compound
Fourier transform spectroscopy
Organization
In situ
Migration
Adsorption isotherm
Confocal microscopy
NMR spectrometry
Hydrophobicity
Porous material
Silica
Aggregation
Infrared spectrum
Release
Drug
Fluid
Desorption
Mesoporosity
Infrared spectrometry
Water soluble compound
Adsorption
Pore
Distribution
Kinetics
Fluorescence microscopy
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Abstract The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material. Understanding this adsorption competition is essential in the development of applications of controlled adsorption and desorption. The poorly water soluble drug compound itraconazole and the fluorescent probe Nile red were selected for the study. The interaction between itraconazole and SBA-15 was investigated using FT-IR, (1)H MAS NMR and (29)Si MAS NMR spectroscopy, by determination of adsorption isotherms and release kinetics in simulated gastric fluid. The distribution and migration of the hydrophobic fluorescent probe Nile red was visualized in situ using confocal fluorescence microscopy. For both molecules, there was a pronounced influence of the co-adsorbed water on adsorption, hydrophobic aggregation and migration in SBA-15 pores. These insights contribute to the development of practical methods for loading ordered mesoporous silica materials with hydrophobic molecules.
AbstractList The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material. Understanding this adsorption competition is essential in the development of applications of controlled adsorption and desorption. The poorly water soluble drug compound itraconazole and the fluorescent probe Nile red were selected for the study. The interaction between itraconazole and SBA-15 was investigated using FT-IR, (1)H MAS NMR and (29)Si MAS NMR spectroscopy, by determination of adsorption isotherms and release kinetics in simulated gastric fluid. The distribution and migration of the hydrophobic fluorescent probe Nile red was visualized in situ using confocal fluorescence microscopy. For both molecules, there was a pronounced influence of the co-adsorbed water on adsorption, hydrophobic aggregation and migration in SBA-15 pores. These insights contribute to the development of practical methods for loading ordered mesoporous silica materials with hydrophobic molecules.
The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material. Understanding this adsorption competition is essential in the development of applications of controlled adsorption and desorption. The poorly water soluble drug compound itraconazole and the fluorescent probe Nile red were selected for the study. The interaction between itraconazole and SBA-15 was investigated using FT-IR, 1H MAS NMR and 29Si MAS NMR spectroscopy, by determination of adsorption isotherms and release kinetics in simulated gastric fluid. The distribution and migration of the hydrophobic fluorescent probe Nile red was visualized in situ using confocal fluorescence microscopy. For both molecules, there was a pronounced influence of the co-adsorbed water on adsorption, hydrophobic aggregation and migration in SBA-15 pores. These insights contribute to the development of practical methods for loading ordered mesoporous silica materials with hydrophobic molecules.
Author MELLAERTS, Randy
AUGUSTIJNS, Patrick
HOFKENS, Johan
VAN DEN MOOTER, Guy
VAN SPEYBROECK, Michiel
HOUTHOOFD, Kristof
JAMMAER, Jasper A. G
MARTENS, Johan A
DE CREMER, Gert
ROEFFAERS, Maarten B. J
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  givenname: Michiel
  surname: VAN SPEYBROECK
  fullname: VAN SPEYBROECK, Michiel
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  givenname: Gert
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  givenname: Jasper A. G
  surname: JAMMAER
  fullname: JAMMAER, Jasper A. G
  organization: Centre for Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Kasteelpark Arenberg 23, 3001 Heverlee, Belgium
– sequence: 7
  givenname: Guy
  surname: VAN DEN MOOTER
  fullname: VAN DEN MOOTER, Guy
  organization: Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, O&N2, Herestraat 49-box 921, 3000 Leuven, Belgium
– sequence: 8
  givenname: Patrick
  surname: AUGUSTIJNS
  fullname: AUGUSTIJNS, Patrick
  organization: Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, O&N2, Herestraat 49-box 921, 3000 Leuven, Belgium
– sequence: 9
  givenname: Johan
  surname: HOFKENS
  fullname: HOFKENS, Johan
  organization: Laboratory of Photochemistry and Spectroscopy, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium
– sequence: 10
  givenname: Johan A
  surname: MARTENS
  fullname: MARTENS, Johan A
  organization: Centre for Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Kasteelpark Arenberg 23, 3001 Heverlee, Belgium
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Issue 7
Keywords Water
Binary compound
Fourier transform spectroscopy
Organization
In situ
Migration
Adsorption isotherm
Confocal microscopy
NMR spectrometry
Hydrophobicity
Porous material
Silica
Aggregation
Infrared spectrum
Release
Drug
Fluid
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Mesoporosity
Infrared spectrometry
Water soluble compound
Adsorption
Pore
Distribution
Kinetics
Fluorescence microscopy
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Snippet The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water...
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StartPage 2706
SubjectTerms Adsorption
Agglomeration
Chemistry
Colloidal state and disperse state
Confocal
Drugs
Exact sciences and technology
Fluorescence
General and physical chemistry
Hydrophobic and Hydrophilic Interactions
Itraconazole - chemistry
Magnetic Resonance Spectroscopy
Migration
Organizations
Oxazines - chemistry
Porosity
Porous materials
Silicon dioxide
Silicon Dioxide - chemistry
Spectroscopy, Fourier Transform Infrared
Surface physical chemistry
Water - chemistry
Title Molecular organization of hydrophobic molecules and co-adsorbed water in SBA-15 ordered mesoporous silica material
URI https://www.ncbi.nlm.nih.gov/pubmed/21152589
https://search.proquest.com/docview/849433588
https://search.proquest.com/docview/963865046
Volume 13
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