Troponin levels after ICD implantation with and without defibrillation testing and their predictive value for outcomes: Insights from the SIMPLE trial

• Published in: Heart rhythm Vol. 13; no. 2; pp. 504 - 510
• Main Authors: Vamos, Mate, MD, Healey, Jeff S., MD, FHRS, Wang, Jia, MSc, Duray, Gabor Z., MD, Connolly, Stuart J., MD, van Erven, Lieselot, MD, Vinolas, Xavier, MD, Neuzner, Jorg, MD, Glikson, Michael, MD, FHRS, Hohnloser, Stefan H., MD, FHRS
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2016
• Subjects: Aged; Cardiomyopathies - complications; Cardiomyopathies - mortality; Cardiomyopathies - therapy; Cardiovascular; Death, Sudden, Cardiac - prevention & control; Defibrillation testing; Defibrillators, Implantable - adverse effects; Electric Countershock - instrumentation; Electric Countershock - methods; Female; Humans; Implantable cardioverter-defibrillator; Long QT Syndrome - complications; Long QT Syndrome - mortality; Long QT Syndrome - therapy; Male; Materials Testing - methods; Middle Aged; Mortality; Outcome Assessment (Health Care); Postoperative Complications - blood; Postoperative Complications - diagnosis; Predictive Value of Tests; Prognosis; Prosthesis Implantation - adverse effects; Prosthesis Implantation - methods; Troponin - blood; Troponin I; Troponin T; RR; defibrillation testing; CI; Shockless IMPLant Evaluation; Mortality; HR; ICD; relative risk; Troponin T; DT; upper limit of normal; Troponin I; ULN; hazard ratio; SIMPLE; confidence interval; implantable cardioverter-defibrillator; Implantable cardioverter-defibrillator; Defibrillation testing

Background The Shockless IMPLant Evaluation trial randomized 2500 patients receiving a first implantable cardioverter-defibrillator (ICD)/cardiac resynchronization therapy-defibrillator device to have either defibrillation testing (DT) or no DT. It demonstrated that DT did not improve shock efficacy...