Antidepressant therapies inhibit inflammation and microglial M1-polarization

• Published in: Pharmacology & therapeutics (Oxford) Vol. 163; pp. 82 - 93
• Main Authors: Kalkman, Hans O., Feuerbach, Dominik
• Format: Journal Article
• Language: English
• Published: England 01.07.2016
• Subjects: Animals; Antidepressive Agents - pharmacology; Biomarkers; Biopterins - analogs & derivatives; Biopterins - metabolism; Depression - drug therapy; Depression - immunology; Electroconvulsive Therapy - methods; Humans; Inflammation - immunology; Inflammation - metabolism; Inflammation - prevention & control; Lipopolysaccharides - toxicity; Macrophages - metabolism; Microglia - classification; Microglia - drug effects; Microglia - metabolism; Phenotype; Risk Factors; Signal Transduction; Stress, Psychological - immunology; Interferon regulatory factor-5; Interferon-α; Respiratory burst; Cyclic AMP response element-binding protein; Glycogen synthase kinase-3β; Nicotinic acetylcholine receptor α7

Macrophages and their counterparts in the central nervous system, the microglia, detect and subsequently clear microbial pathogens and injured tissue. These phagocytic cells alter and adapt their phenotype depending on their prime activity, i.e., whether they participate in acute defence against pat...