N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression

• Published in: Molecular cell Vol. 81; no. 16; pp. 3339 - 3355.e8
• Main Authors: Dai, Zihao, Liu, Haining, Liao, Junbin, Huang, Cheng, Ren, Xiaoxue, Zhu, Wanjie, Zhu, Shenghua, Peng, Baogang, Li, Shaoqiang, Lai, Jiaming, Liang, Lijian, Xu, Lixia, Peng, Sui, Lin, Shuibin, Kuang, Ming
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 19.08.2021
• Subjects: animal disease models; biliary tract diseases; cell cycle; cell viability; epidermal growth factor receptors; G-proteins; gain-of-function mutation; gene overexpression; guanosine; knockout mutants; liver neoplasms; messenger RNA; methyltransferases; mice; neoplasm cells; neoplasm progression; oncogenes; transfer RNA; translation (genetics)

Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate cancer survival and progression, but the underlying mechanisms are poorly understood. Here, we find that N7-methylguanosine (m7G) tRNA modification and its methyltransferase complex components, METTL1 and WD...