Fabrication of bioactive conduits containing the fibroblast growth factor 1 and neural stem cells for peripheral nerve regeneration across a 15 mm critical gap

• Published in: Biofabrication Vol. 5; no. 3; pp. 35010 - 35023
• Main Authors: Ni, Hsiao-Chiang, Tseng, Ting-Chen, Chen, Jeng-Rung, Hsu, Shan-hui, Chiu, Ing-Ming
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 01.09.2013
• Subjects: air plasma; Animals; fibroblast growth factor; Fibroblast Growth Factor 1 - metabolism; Male; micropattern; Nerve Regeneration; neural stem cells; Neural Stem Cells - cytology; Neural Stem Cells - metabolism; peripheral nerve regeneration; Polymers - chemistry; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Sciatic Nerve - injuries; Sciatic Nerve - physiology; Tissue Engineering - instrumentation; Tissue Scaffolds - chemistry

Nerve conduits are often used in combination with bioactive molecules and stem cells to enhance peripheral nerve regeneration. In this study, the acidic fibroblast growth factor 1 (FGF1) was immobilized onto the microporous micropatterned poly (D, L-lactic acid) (PLA) nerve conduits after open air p...