High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults

• Published in: Diabetes care Vol. 42; no. 11; pp. 2117 - 2126
• Main Authors: Lu, Jieli, Lam, Sin Man, Wan, Qin, Shi, Lixin, Huo, Yanan, Chen, Lulu, Tang, Xulei, Li, Bowen, Wu, Xueyan, Peng, Kui, Li, Mian, Wang, Shuangyuan, Xu, Yu, Xu, Min, Bi, Yufang, Ning, Guang, Shui, Guanghou, Wang, Weiqing
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.11.2019
• Subjects: Adults; Correlation analysis; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Esters; Evaluation; Fatty acids; Glucose; Lipids; Network analysis; Polyunsaturated fatty acids; Predictions; Research design; Serum lipids; Tags; Triglycerides

Comprehensive assessment of serum lipidomic aberrations before type 2 diabetes (T2DM) onset has remained lacking in Han Chinese. We evaluated changes in lipid coregulation antecedent to T2DM and identified novel lipid predictors for T2DM in individuals with normal glucose regulation (NGR). In the di...