Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex

• Published in: Science advances Vol. 5; no. 6; p. eaaw3307
• Main Authors: Chiner-Oms, Á., Sánchez-Busó, L., Corander, J., Gagneux, S., Harris, S. R., Young, D., González-Candelas, F., Comas, I.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 01.06.2019
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Datasets as Topic; Gene Expression; Genetic Loci; Genetic Speciation; Genetics; Genome, Bacterial; History, 21st Century; History, Ancient; Host-Pathogen Interactions - genetics; Humans; Microbiology; Mutation; Mycobacterium - classification; Mycobacterium - genetics; Mycobacterium - metabolism; Mycobacterium - pathogenicity; Mycobacterium tuberculosis - classification; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - metabolism; Mycobacterium tuberculosis - pathogenicity; Phylogeny; Recombination, Genetic; SciAdv r-articles; Selection, Genetic; Tuberculosis - epidemiology; Tuberculosis - genetics; Tuberculosis - history; Tuberculosis - microbiology; Virulence; Virulence Factors - genetics; Virulence Factors - metabolism

Emergence and global success of tuberculosis involve core pathogenesis functions under selection in epidemiological settings. Models on how bacterial lineages differentiate increase our understanding of early bacterial speciation events and the genetic loci involved. Here, we analyze the population...