MK-801 produces a deficit in sucrose preference that is reversed by clozapine, d-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: Relevance to negative symptoms associated with schizophrenia?

• Published in: Pharmacology, biochemistry and behavior Vol. 95; no. 2; pp. 223 - 229
• Main Authors: Vardigan, Joshua D., Huszar, Sarah L., McNaughton, Caitlyn H., Hutson, Peter H., Uslaner, Jason M.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Inc 01.04.2010; Elsevier
• Subjects: Adult and adolescent clinical studies; Allosteric properties; Allosteric Regulation; Anhedonia; Animals; Benzamides - pharmacology; Biological and medical sciences; Clozapine - pharmacology; Dizocilpine Maleate - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; Male; Medical sciences; Metabotropic glutamate receptor; Negative symptoms; Neuropharmacology; NMDA; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Psychoses; Pyrazoles - pharmacology; Quinine - administration & dosage; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate - drug effects; Schizophrenia; Schizophrenia - physiopathology; Serine - pharmacology; Sucrose - administration & dosage; NMDA; Schizophrenia; Anhedonia; Negative symptoms; Metabotropic glutamate receptor; Dibenzodiazepine derivatives; Atypical antipsychotic; Sucrose; Neuroleptic; Psychotropic; Serine; Glutamate receptor; Psychosis; Negative symptom; Antagonist; mglu5 glutamate receptor; Dizocilpine; Neuroprotective agent; Clozapine; D2 Dopamine receptor; Metabotropic receptor; Allosteric regulation; Preference; Aminoacid; NMDA receptor

Currently prescribed antipsychotics attenuate the positive symptoms of schizophrenia but fail or only mildly improve negative symptoms. The present study aimed to establish an animal model of negative symptoms by examining the effects of the NMDA receptor antagonist MK-801 on sucrose preference. We...