MK-801 produces a deficit in sucrose preference that is reversed by clozapine, d-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: Relevance to negative symptoms associated with schizophrenia? - Vardigan, Joshua D.; Huszar, Sarah L.; McNaughton, Caitlyn H.; Hutson, Peter H.; Uslaner, Jason M. (Pharmacology, biochemistry and behavior, 2010)
Keywords: Adult and adolescent clinical studies; Allosteric properties; Allosteric Regulation; Anhedonia; Animals; Benzamides - pharmacology; Biological and medical sciences; Clozapine - pharmacology; Dizocilpine Maleate - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; Male; Medical sciences; Metabotropic glutamate receptor; Negative symptoms; Neuropharmacology; NMDA; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Psychoses; Pyrazoles - pharmacology; Quinine - administration & dosage; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate - drug effects; Schizophrenia; Schizophrenia - physiopathology; Serine - pharmacology; Sucrose - administration & dosage; NMDA; Schizophrenia; Anhedonia; Negative symptoms; Metabotropic glutamate receptor; Dibenzodiazepine derivatives; Atypical antipsychotic; Sucrose; Neuroleptic; Psychotropic; Serine; Glutamate receptor; Psychosis; Negative symptom; Antagonist; mglu5 glutamate receptor; Dizocilpine; Neuroprotective agent; Clozapine; D2 Dopamine receptor; Metabotropic receptor; Allosteric regulation; Preference; Aminoacid; NMDA receptor