High Plasma Polyamine Levels Are Associated With an Increased Risk of Poststroke Cognitive Impairment: A Multicenter Prospective Study From CATIS

• Published in: Journal of the American Heart Association Vol. 14; no. 2; p. e037465
• Main Authors: He, Yu, Jia, Yiming, Liu, Yi, Chang, Xinyue, Yang, Pinni, Shi, Mengyao, Guo, Daoxia, Peng, Yanbo, Chen, Jing, Wang, Aili, Xu, Tan, He, Jiang, Zhang, Yonghong, Zhu, Zhengbao
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 21.01.2025; Wiley
• Subjects: Aged; Biomarkers - blood; China - epidemiology; Cognition; Cognitive Dysfunction - blood; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - epidemiology; Cognitive Dysfunction - etiology; cognitive impairment; Female; Humans; ischemic stroke; Ischemic Stroke - blood; Ischemic Stroke - complications; Ischemic Stroke - diagnosis; Ischemic Stroke - psychology; Male; Middle Aged; Original Research; polyamines; Polyamines - blood; prognosis; Prospective Studies; Putrescine - blood; Risk Assessment; Risk Factors; Spermidine - blood; Spermine - blood; Stroke - blood; Stroke - complications; Stroke - diagnosis; Stroke - psychology; China; risk factors; cognitive impairment; polyamines; prognosis; ischemic stroke

Polyamines have been suggested to play pivotal roles in ischemic stroke and neurodegenerative disorders, but the associations of plasma polyamines with poststroke cognitive impairment (PSCI) remain unclear. We aimed to prospectively investigate the associations of plasma putrescine, spermidine, and...