Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation

• Published in: Experimental neurology Vol. 323; p. 113066
• Main Authors: Liu, Jin-Hui, Wang, Tse-Wen, Lin, Yung-Yang, Ho, Wen-Chien, Tsai, Hong-Chieh, Chen, Shih-Pin, Lin, Anya Maan-Yuh, Liu, Tsung-Yun, Wang, Hsiang-Tsui
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2020
• Subjects: 3-HPMA; Acrolein; Glutathione; Ischemic stroke; Neurotoxicity; SSAT; Acrolein; Neurotoxicity; Ischemic stroke; 3-HPMA; SSAT; Glutathione

Ischemic stroke is the most common type of cerebrovascular event and is responsible for approximately 85% of all strokes in Taiwan. Neurons contain high concentrations of polyamines, which are prone to various pathological states in the brain and are perturbed after cerebral ischemia. Acrolein, an α...