Molecular Cloning and Characterization of the G Protein γ Subunit of Cone Photoreceptors

• Published in: The Journal of biological chemistry Vol. 270; no. 15; pp. 8495 - 8500
• Main Authors: Ong, Olivia C., Yamane, Harvey K., Phan, Kim B., Fong, Henry K.W., Bok, Dean, Lee, Rehwa H., Fung, Bernard K.-K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.04.1995
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Cattle; Cloning, Molecular; DNA, Complementary; GTP-Binding Proteins - genetics; GTP-Binding Proteins - immunology; GTP-Binding Proteins - metabolism; Immune Sera; Immunohistochemistry; Molecular Sequence Data; Protein Prenylation; Retinal Cone Photoreceptor Cells - metabolism; RNA, Messenger - metabolism; Sequence Homology, Amino Acid

The phototransduction process in cones has been proposed to involve a G protein that couples the signal from light-activated visual pigment to the effector cyclic GMP phosphodiesterase. Previously, we have identified and purified a Gβγ complex composed of a Gβ3isoform and an immunochemically distinc...