Optimal transport reveals immune perturbation and fingerprints over time in COVID-19 vaccination

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 250; p. 10445
• Main Authors: Wang, Zexuan, Chen, Jiong, Ionita, Matei, Zhan, Qipeng, Zhou, Zhuoping, Shen, Li
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.05.2025
• Subjects: CD3 Complex - immunology; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 vaccination; COVID-19 Vaccines - immunology; Experimental Biology and Medicine; fingerprint; Flow Cytometry - methods; Humans; immunity; Leukocyte Common Antigens - immunology; mass cytometry; optimal transport; SARS-CoV-2 - immunology; Vaccination; fingerprint; optimal transport; immunity; mass cytometry; COVID-19 vaccination

Mass cytometry enables high-throughput characterization of heterogeneous cell populations at single-cell resolution, using metal isotopes to capture cellular signals and avoiding the spectral overlap common in flow cytometry. Despite advancements, conventional data analysis often focuses on manual g...