NAD + metabolism and retinal degeneration (Review)
The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide (NAD ), particularly in regards to its intermediates, such as nicotinamide and nicotinic acid known as niacin, and also nicotinamide riboside. Besides its participation as a coenzyme in the redox tran...
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Published in | Experimental and therapeutic medicine Vol. 22; no. 1; p. 670 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
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Spandidos Publications UK Ltd
01.07.2021
D.A. Spandidos |
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Abstract | The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide (NAD
), particularly in regards to its intermediates, such as nicotinamide and nicotinic acid known as niacin, and also nicotinamide riboside. Besides its participation as a coenzyme in the redox transformations of nutrients during catabolism, NAD
is also involved in DNA repair and epigenetic modification of gene expression and also plays an essential role in calcium homeostasis. Clinical and experimental data emphasize the age-dependent decline in NAD
levels and its relation with the onset and progression of various age-related diseases. Maintaining optimal levels of NAD
has aroused a therapeutic interest in such pathological conditions; NAD
being currently regarded as an important target to extend health and lifespan. Based on a systematic exploration of the experimental data and literature surrounding the topic, this paper reviews some of the recent research studies related to the roles of the pyridine nucleotide family focusing on biosynthesis, NAD
deficiency-associated diseases, pathobiochemistry related to retinal degeneration and potential therapeutic effects on human vision as well. |
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AbstractList | The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide (NAD
), particularly in regards to its intermediates, such as nicotinamide and nicotinic acid known as niacin, and also nicotinamide riboside. Besides its participation as a coenzyme in the redox transformations of nutrients during catabolism, NAD
is also involved in DNA repair and epigenetic modification of gene expression and also plays an essential role in calcium homeostasis. Clinical and experimental data emphasize the age-dependent decline in NAD
levels and its relation with the onset and progression of various age-related diseases. Maintaining optimal levels of NAD
has aroused a therapeutic interest in such pathological conditions; NAD
being currently regarded as an important target to extend health and lifespan. Based on a systematic exploration of the experimental data and literature surrounding the topic, this paper reviews some of the recent research studies related to the roles of the pyridine nucleotide family focusing on biosynthesis, NAD
deficiency-associated diseases, pathobiochemistry related to retinal degeneration and potential therapeutic effects on human vision as well. The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide (NAD+), particularly in regards to its intermediates, such as nicotinamide and nicotinic acid known as niacin, and also nicotinamide riboside. Besides its participation as a coenzyme in the redox transformations of nutrients during catabolism, NAD+ is also involved in DNA repair and epigenetic modification of gene expression and also plays an essential role in calcium homeostasis. Clinical and experimental data emphasize the age-dependent decline in NAD+ levels and its relation with the onset and progression of various age-related diseases. Maintaining optimal levels of NAD+ has aroused a therapeutic interest in such pathological conditions; NAD+ being currently regarded as an important target to extend health and lifespan. Based on a systematic exploration of the experimental data and literature surrounding the topic, this paper reviews some of the recent research studies related to the roles of the pyridine nucleotide family focusing on biosynthesis, NAD+ deficiency-associated diseases, pathobiochemistry related to retinal degeneration and potential therapeutic effects on human vision as well. The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide (NAD + ), particularly in regards to its intermediates, such as nicotinamide and nicotinic acid known as niacin, and also nicotinamide riboside. Besides its participation as a coenzyme in the redox transformations of nutrients during catabolism, NAD + is also involved in DNA repair and epigenetic modification of gene expression and also plays an essential role in calcium homeostasis. Clinical and experimental data emphasize the age-dependent decline in NAD + levels and its relation with the onset and progression of various age-related diseases. Maintaining optimal levels of NAD + has aroused a therapeutic interest in such pathological conditions; NAD + being currently regarded as an important target to extend health and lifespan. Based on a systematic exploration of the experimental data and literature surrounding the topic, this paper reviews some of the recent research studies related to the roles of the pyridine nucleotide family focusing on biosynthesis, NAD + deficiency-associated diseases, pathobiochemistry related to retinal degeneration and potential therapeutic effects on human vision as well. |
ArticleNumber | 670 |
Author | Andrei, Ana Marina Pîrvu, Andreea Silvia Jurja, Sanda Ciuluvica, Radu Stănciulescu, Elena Camelia Pisoschi, Cătălina Gabriela Baniță, Ileana Monica |
AuthorAffiliation | 1 Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 2 Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 5 Faculty of Dentistry, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania 3 Department of Histology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 4 Department of Ophthalmology, Faculty of Medicine, ‘Ovidius’ University of Constanta, 900527 Constanta, Romania |
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Keywords | NAD niacin pyridine nucleotide family retinal degeneration nicotinamide riboside NAD+ therapeutic target |
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Snippet | The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide (NAD
), particularly in regards to its intermediates, such... The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide (NAD+), particularly in regards to its intermediates, such... The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide (NAD + ), particularly in regards to its intermediates,... |
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StartPage | 670 |
SubjectTerms | Aging Biosynthesis Cancer therapies Cell cycle Cell division Cognitive ability Diabetes Diet DNA repair Enzymes Epigenetics Gene expression Homeostasis Investigations Kinases Metabolic disorders Metabolic syndrome Metabolites Oxidation Pharmacokinetics Phosphorylation Review Rodents Vitamin B |
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Title | NAD + metabolism and retinal degeneration (Review) |
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