Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats - Sirichoat, Apiwat; Suwannakot, Kornrawee; Chaisawang, Pornthip; Pannangrong, Wanassanun; Aranarochana, Anusara; Wigmore, Peter; Welbat, Jariya Umka (Life sciences (1973), 2020)
Keywords: 5-Fluorouracil; adults; Animal behavior; Animal memory; Animal models; Animals; Antimetabolites - adverse effects; Biomarkers - metabolism; Bromodeoxyuridine; Cell Proliferation - drug effects; Chemotherapy; Cognitive ability; cognitive disorders; Cognitive Dysfunction - drug therapy; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - physiopathology; Dentate Gyrus - drug effects; Dentate Gyrus - metabolism; Dentate Gyrus - pathology; Doublecortin protein; Drug Administration Schedule; fluorouracil; Fluorouracil - adverse effects; Fluorouracil - antagonists & inhibitors; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Immunohistochemistry; Impairment; Injections, Intravenous; Intravenous administration; intravenous injection; Ki-67 Antigen - genetics; Ki-67 Antigen - metabolism; Male; males; Melatonin; Melatonin - pharmacology; Memory; memory disorders; Memory Disorders - drug therapy; Memory Disorders - metabolism; Memory Disorders - physiopathology; Memory tasks; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; neonates; Neurogenesis; Neurogenesis - drug effects; Neurogenesis - genetics; neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuropeptides - genetics; Neuropeptides - metabolism; Neuroprotection; Neuroprotective Agents - pharmacology; neuroprotective effect; patients; photoperiod; Rats; Rats, Sprague-Dawley; Spatial analysis; Spatial memory; Spatial Memory - drug effects; Spatial Memory - physiology; 5-fluorouracil; Melatonin; Neurogenesis; Hippocampus; Spatial memory