Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

• Published in: Circulation (New York, N.Y.) Vol. 122; no. 9; pp. 920 - 927
• Main Authors: Soon, Elaine, Holmes, Alan M., Treacy, Carmen M., Doughty, Natalie J., Southgate, Laura, Machado, Rajiv D., Trembath, Richard C., Jennings, Simon, Barker, Lucy, Nicklin, Paul, Walker, Christoph, Budd, David C., Pepke-Zaba, Joanna, Morrell, Nicholas W.
• Format: Journal Article
• Language: English
• Published: United States 31.08.2010
• Subjects: Adult; Aged; Biomarkers - blood; Blood Pressure; Bone Morphogenetic Protein Receptors, Type II - genetics; Cytokines - blood; Female; Genetic Predisposition to Disease; Humans; Hypertension, Pulmonary - diagnosis; Hypertension, Pulmonary - genetics; Hypertension, Pulmonary - mortality; Inflammation - diagnosis; Inflammation - genetics; Inflammation - mortality; Inflammation Mediators - blood; Kaplan-Meier Estimate; Male; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Analysis; Vascular Resistance

Background— Inflammation is a feature of pulmonary arterial hypertension (PAH), and increased circulating levels of cytokines are reported in patients with PAH. However, to date, no information exists on the significance of elevated cytokines or their potential as biomarkers. We sought to determine...